Hinweis: Die hier aufgeführten Studien dienen ausschließlich der allgemeinen wissenschaftlichen Information. Sie beziehen sich auf einzelne Inhaltsstoffe und nicht auf konkrete Produkte. Die genannten Studien stellen keine gesundheitsbezogenen Aussagen im Sinne der EU-Health-Claims-Verordnung dar.

• Asserin, J. et al. (2015) – The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials. 

https://pubmed.ncbi.nlm.nih.gov/26362110/

• Bölke, L. et al. (2019) – A Collagen Supplement Improves Skin Hydration, Elasticity, Roughness, and Density: Results of a Randomized, Placebo-Controlled, Blind Study. 

https://pubmed.ncbi.nlm.nih.gov/31627309/

• Choi, F. D. et al. (2019) -  Oral collagen supplementation: A systematic review of dermatological applications

https://pubmed.ncbi.nlm.nih.gov/30681787/

• Danessa G. et al. (2025) — Effects of collagen-based supplements on skin hydration and elasticity: a systematic review and meta-analysis 

https://ijdvl.com/effects-of-collagen-based-supplements-on-skins-hydration-and-elasticity-a-systematic-review-and-meta-analysis/  

• De Miranda, R. B. et al. (2021) - Effects of hydrolyzed collagen supplementation on skin aging: A systematic review and meta-analysis

https://doi.org/10.1111/ijd.15518

• Gibson R. et al. (2024) — Beneficial Effects of Multi-Micronutrient Supplementation with Collagen Peptides on Global Wrinkles, Skin Elasticity and Appearance in Healthy Female Subjects

https://link.springer.com/article/10.1007/s13555-024-01184-2?utm

• Oesser, S. (2020) - The oral intake of specific bioactive collagen peptides has a positive effect on hair thickness

https://doi.org/10.17470/NF-020-0019

• Pappelbaum K. et al. (2024) - Revealing novel insights on how oral supplementation with collagen peptides may prevent hair loss: Lessons from the human hair follicle organ culture

https://www.sciencedirect.com/science/article/pii/S1756464624001269?via%3Dihub

• Proksch, E. et al. (2014) – Oral Intake of Specific Bioactive Collagen Peptides Reduces Skin Wrinkles and Increases Dermal Matrix Synthesis. 

https://karger.com/spp/article-abstract/27/3/113/295769/Oral-Intake-of-Specific-Bioactive-Collagen?redirectedFrom=fulltext&utm

• Proksch, E. et al. (2014) – Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, placebo-controlled study. 

https://pubmed.ncbi.nlm.nih.gov/23949208/

• Pu S.-Y. et al. (2023) — Effects of Oral Collagen for Skin Anti-Aging: A Systematic Review and Meta-Analysis

https://pmc.ncbi.nlm.nih.gov/articles/PMC10180699/

• Reilly D.M., et al. (2024) — A Clinical Trial Shows Improvement in Skin Collagen, Hydration, Elasticity, Wrinkles, Scalp, and Hair Condition following 12-Week Oral Intake of a Supplement Containing Hydrolysed Collagen

https://pubmed.ncbi.nlm.nih.gov/39021368/

• Van Wicklin S.A. (2023) - Natural Hair Supplements: Biotin and Collagen

https://learning.lww.com/ovidfiles/02272668-202307000-00004.pdf?utm

• Virgilio N., et al., 2024 — Absorption of bioactive peptides following collagen hydrolysate intake 

https://www.frontiersin.org/articles/10.3389/fnut.2024.1416643/full

• Žmitek K. et al. (2024) - The Effects of Dietary Supplementation with Collagen and Vitamin C and Their Combination with Hyaluronic Acid on Skin Density, Texture and Other Parameters: A Randomised, Double-Blind, Placebo-Controlled Trial.

https://pmc.ncbi.nlm.nih.gov/articles/PMC11206740/?utm

• Yan-Rui G. et al. (2023) - Oral administration of hyaluronic acid to improve skin conditions via a randomized double-blind clinical test

https://pmc.ncbi.nlm.nih.gov/articles/PMC10661223/?utm

• Göllner I. et al. (2017) - Ingestion of an Oral Hyaluronan Solution Improves Skin Hydration, Wrinkle Reduction, Elasticity and Skin Roughness: Results of a Clinical Study.

https://www.researchgate.net/publication/321512333_Ingestion_of_an_Oral_Hyaluronan_Solution_Improves_Skin_Hydration_Wrinkle_Reduction_Elasticity_and_Skin_Roughness_Results_of_a_Clinical_Study

• Tzu-Fang H. et al. (2021) - Oral Hyaluronan Relieves Wrinkles and Improves Dry Skin 

https://pmc.ncbi.nlm.nih.gov/articles/PMC8308347/ PMC

• Žmitek K. et al. (2024) - The Effects of Dietary Supplementation with Collagen and Vitamin C and Their Combination with Hyaluronic Acid on Skin Density, Texture and Other Parameters: A Randomised, Double-Blind, Placebo-Controlled Trial

https://pmc.ncbi.nlm.nih.gov/articles/PMC11206740/?utm

• Boo Y.C., (2022) — Ascorbic Acid (Vitamin C) as a Cosmeceutical to Increase Cutaneous Collagen 

https://www.mdpi.com/2076-3921/11/9/1663

• Laurindo L.F. et al. (2024) — Health benefits of acerola (Malpighia spp.) and its by-products: Health benefits of acerola (Malpighia spp) and its by-products: A comprehensive review of nutrient-rich composition, pharmacological potential, and industrial applications

https://www.sciencedirect.com/science/article/pii/S2212429224018534

• Prakash A., et al. (2018) — Acerola, an untapped functional superfruit: a review on latest frontiers

https://pmc.ncbi.nlm.nih.gov/articles/PMC6098779/ 

• Reilly D.M., et al. (2024) — A Clinical Trial Shows Improvement in Skin Collagen, Hydration, Elasticity, Wrinkles, Scalp, and Hair Condition following 12-Week Oral Intake of a Supplement Containing Hydrolysed Collagen

https://pubmed.ncbi.nlm.nih.gov/39021368/

• Žmitek K. et al. (2024) - The Effects of Dietary Supplementation with Collagen and Vitamin C and Their Combination with Hyaluronic Acid on Skin Density, Texture and Other Parameters: A Randomised, Double-Blind, Placebo-Controlled Trial.

https://pmc.ncbi.nlm.nih.gov/articles/PMC11206740/?utm

• Fuchs J. et al. (1998) — Modulation of UV-light-induced skin inflammation by D-alpha-tocopherol and L-ascorbic acid: a clinical study using solar simulated radiation. 

https://pubmed.ncbi.nlm.nih.gov/9870553/ 

• Lima XT et al. (2012) — A Double-Blinded, Randomized, Controlled Trial to Evaluate an Oral Antioxidant Combination on Skin Biophysical Properties

https://pmc.ncbi.nlm.nih.gov/articles/PMC3366441/ 

• Baswan SM et al. (2021) — Role of ingestible carotenoids in skin protection: A review of clinical evidence

https://onlinelibrary.wiley.com/doi/10.1111/phpp.12690?utm

• Fisher GJ et al. (1997) — Pathophysiology of Premature Skin Aging Induced by Ultraviolet Light

https://www.nejm.org/doi/full/10.1056/NEJM199711133372003?utm

• Heinrich U. et al. (2003) — Supplementation with beta-carotene or a carotenoid mix protects against UV-induced erythema

https://pubmed.ncbi.nlm.nih.gov/12514275/

• Varani J et al. (2000) — Vitamin A antagonizes decreased cell growth and elevated collagen-degrading MMPs in naturally aged skin

https://pubmed.ncbi.nlm.nih.gov/10692106/

• Gibson R. et al. (2024) — Beneficial Effects of Multi-Micronutrient Supplementation with Collagen Peptides on Global Wrinkles, Skin Elasticity and Appearance in Healthy Female Subjects

https://link.springer.com/article/10.1007/s13555-024-01184-2?utm

• Laronha H. et al. (2020) — Structure and Function of Human Matrix Metalloproteinases

https://pmc.ncbi.nlm.nih.gov/articles/PMC7290392/ 

• Lin P.-H. et al. (2017) — Zinc in Wound Healing Modulation

https://pmc.ncbi.nlm.nih.gov/articles/PMC5793244/

• Ablon G. et al. (2018) „A six-month, randomized, double-blind, placebo-controlled study evaluating the safety and efficacy of a nutraceutical supplement for promoting hair growth in women with self-perceived thinning hair

https://learning.lww.com/ovidfiles/02272668-202307000-00004.pdf?utm_source=chatgpt.com

• Kalman D.S., et al. (2021) - A Randomized Double-Blind Evaluation of a Novel Biotin and Silicon Ingredient Complex on the Hair and Skin of Healthy Women

https://www.longdom.org/open-access/a-randomized-doubleblind-evaluation-of-a-novel-biotin-and-silicon-ingredient-complex-on-the-hair-and-skin-of-healthy-women-61185.html ResearchGate+1

• Patel M.N. et al. (2025) -  The Role of Sesbania grandiflora-Derived Biotin and Bambusa arundinacea-Derived Silica Extracts in Promoting Hair, Skin, and Nail Health: A Randomized, Double-Blind, Placebo-Controlled Clinical Study

https://www.cureus.com/articles/385055-the-role-of-sesbania-grandiflora-derived-biotin-and-bambusa-arundinacea-derived-silica-extracts-in-promoting-hair-skin-and-nail-health-a-randomized-double-blind-placebo-controlled-clinical-study.pdf

• Fam V.W. et al. (2022) – Plant-Based Foods for Skin Health: A Narrative Review

https://www.sciencedirect.com/science/article/pii/S2212267221014337?utm

• Fan L. et al. (2024) – Deciphering UVA/Riboflavin Collagen Crosslinking: A Molecular Level Study

https://advanced.onlinelibrary.wiley.com/journal/16163028

• Jiang N. et al. (2025) – Role of Nutritional Elements in Skin Homeostasis: A Review

https://www.mdpi.com/2218-273X/15/6/808?utm

• Bains, P et al. (2018) - Nicotinamide: Mechanism of action and indications in dermatology

https://pubmed.ncbi.nlm.nih.gov/29405129/

Durch seine antiinflammatorischen, antioxidativen und barrierestärkenden Eigenschaften hat Vitamin B3 vielfältige positive Effekte auf die Haut – darunter verbesserte Barrierefunktion, erhöhte Kollagensynthese, reduzierte Hyperpigmentierung und Schutz vor UV-bedingten Hautschäden.

• Chen AC et al. (2016) — Oral nicotinamide reduces transepidermal water loss: a randomized controlled trial

https://pubmed.ncbi.nlm.nih.gov/27062605/

Die Einnahme von Vitamin B3 stärkt die Haut von innen, indem sie den natürlichen Feuchtigkeitsverlust verringert – ein Zeichen für eine gesunde, widerstandsfähige Hautbarriere.

• Mahmud R. et al (2022) - Impact of gut microbiome on skin health: gut-skin axis observed through the lenses of therapeutics and skin diseases

https://pmc.ncbi.nlm.nih.gov/articles/PMC9311318/?utm

• Zeng M. et al. (2023) -  Prebiotic Oligosaccharides in Skin Health: Benefits, Mechanisms, and Cosmetic Applications

https://www.mdpi.com/2076-3921/14/6/754?utm

• Gambioli R. et al. (2021) - Myo-Inositol as a Key Supporter of Fertility and Physiological Gestation

https://www.mdpi.com/1424-8247/14/6/504

• Gianfranco C. et al. (2011) — Myo-inositol in the treatment of premenstrual dysphoric disorder

https://pubmed.ncbi.nlm.nih.gov/22031267/

• Giordano D. et al. (2011) — Effects of myo-inositol supplementation in postmenopausal women with metabolic syndrome: a prospective, randomized, placebo-controlled study

https://journals.lww.com/menopausejournal/abstract/2011/01000/effects_of_myo_inositol_supplementation_in.20.aspx)

• Payer J. et al. (2022) - Supplementation with myo-inositol and Selenium improves the clinical conditions and biochemical features of women with or at risk for subclinical hypothyroidism 

https://pmc.ncbi.nlm.nih.gov/articles/PMC9709133/?utm_source=chatgpt.com

• Unfer V. et al. (2017) - Myo-inositol effects in women with PCOS: a meta-analysis of randomized controlled trials

https://pmc.ncbi.nlm.nih.gov/articles/PMC5655679/?utm_source=chatgpt.com

• Begum S. S. et al. (2016) - A Novel Extract of Fenugreek Husk (FenuSMART™) Alleviates Postmenopausal Symptoms and Helps to Establish the Hormonal Balance: A Randomized, Double-Blind, Placebo-Controlled Study

https://pubmed.ncbi.nlm.nih.gov/27406028/

• Khanna A. et al. (2020) - Efficacy of a novel extract of fenugreek seeds in alleviating vasomotor symptoms and depression in perimenopausal women: A randomized, double-blinded, placebo-controlled study

https://pubmed.ncbi.nlm.nih.gov/33025616/

• Khanna A. et al. (2021) - Safety and influence of a novel extract of fenugreek on healthy young women: a randomized, double-blinded, placebo-controlled study

https://clinphytoscience.springeropen.com/articles/10.1186/s40816-021-00296-y?utm

• Steels E. et al., 2017 - Efficacy of a Proprietary Trigonella foenum-graecum L. De-Husked Seed Extract in Reducing Menopausal Symptoms in Otherwise Healthy Women: A Double-Blind, Randomized, Placebo-Controlled Study

https://pubmed.ncbi.nlm.nih.gov/28707431/

• Agha-Hosseini M. et al. (2008) - Crocus sativus L. (saffron) in the treatment of premenstrual syndrome: a double-blind, randomised and placebo-controlled trial

https://pubmed.ncbi.nlm.nih.gov/18271889/

• Delam H. et al. (2023) - The effect of Crocus sativus L. (saffron) herbal tea on happiness in postmenopausal women: a randomized controlled trial

https://bmccomplementmedtherapies.biomedcentral.com/articles/10.1186/s12906-023-04014-8?utm

• Lopresti A. et al. (2021) - The Effects of a Saffron Extract (affron®) on Menopausal Symptoms in Women during Perimenopause: A Randomised, Double-Blind, Placebo-Controlled Study

https://e-jmm.org/DOIx.php?id=10.6118/jmm.21002

• Doll H. et al., (1989) — Pyridoxine (vitamin B6) and the premenstrual syndrome: a randomized crossover trial

https://pubmed.ncbi.nlm.nih.gov/2558186/

• O Kennedy D. (2016) - B Vitamins and the Brain: Mechanisms, Dose and Efficacy — A Review

https://pmc.ncbi.nlm.nih.gov/articles/PMC4772032/?utm

• Schellack N. et al. (2024) - Expert Consensus on Vitamin B6 Therapeutic Use for Patients

https://www.dovepress.com/expert-consensus-on-vitamin-b6-therapeutic-use-for-patients-guidance-o-peer-reviewed-fulltext-article-DHPS?utm

• Soheila, S et al. (2016) - Effects of vitamin B6 on premenstrual syndrome: A systematic review and meta-analysis.

https://www.researchgate.net/publication/309104863_Effects_of_vitamin_B6_on_premenstrual_syndrome_A_systematic_review_and_meta-Analysis

• Facchinetti F. et al. (1991) - Oral magnesium successfully relieves premenstrual mood changes 

https://pubmed.ncbi.nlm.nih.gov/2067759/

• Fathizadeh N. et al. (2010) - Evaluating the effect of magnesium and magnesium plus vitamin B6 on the severity of premenstrual syndrome

https://pmc.ncbi.nlm.nih.gov/articles/PMC3208934/

• Li R. et al (2022) - A systematic review: The effect of magnesium supplementation alone or in combination on inflammation, oxidative stress and metabolism in women with PCOS

https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2022.974042/full?utm

• Schuster J. et al. (2025) - Magnesium bisglycinate supplementation in healthy adults reporting poor sleep quality

https://pmc.ncbi.nlm.nih.gov/articles/PMC12412596/

• Zhang Y. et al. (2021) - Association of magnesium intake with sleep duration and sleep quality in US adults

https://pmc.ncbi.nlm.nih.gov/articles/PMC8996025/

• Baek J. H. et al. (2018) - Effect of Korean Red Ginseng in individuals exposed to high stress: a double-blind RCT.

https://pmc.ncbi.nlm.nih.gov/articles/PMC6606819/?utm

• Kim H.-G. et al. (2013) - Antifatigue Effects of Panax ginseng C.A. Meyer: : A Randomised, Double-Blind, Placebo-Controlled Trial

https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0061271&utm

• Shim Y. et al. (2025) - Effects of white ginseng on reducing stress and tension by enhancing default mode network connectivity: A randomized, double-blinded placebo-controlled clinical trial.

https://www.researchgate.net/publication/394514214_Effects_of_white_ginseng_on_reducing_stress_and_tension_by_enhancing_default_mode_network_connectivity_A_randomized_double-blinded_placebo-controlled_clinical_trial

• Yoon J. et al. (2023) - The effects of Korean Red Ginseng on stress-related neurotransmitters and gene expression: A randomized, double-blind, placebo-controlled trial

https://www.sciencedirect.com/science/article/pii/S1226845323001069?utm

• Donath F. et al. (2000) - Critical evaluation of the effect of valerian extract on sleep structure and sleep quality.

https://pubmed.ncbi.nlm.nih.gov/10761819/

• Fernández-San-Martín M. I. et al. (2010) - Effectiveness of Valerian on insomnia: a meta-analysis of randomized placebo-controlled trials

https://pubmed.ncbi.nlm.nih.gov/20347389/

Studien, die Kombinationen mit Baldrian (synergistisch) in Bezug auf Beruhigung/Angst (nicht nur Schlaf) untersucht haben:

• Dodd F. et al. (2022) - The chronic effects of a combination of herbal extracts (Euphytose®) on psychological mood state and response to a laboratory stressor https://pmc.ncbi.nlm.nih.gov/articles/PMC9643820/
  
  
• Koetter U. et al. (2007) - A randomized, double blind, placebo-controlled, prospective clinical study to demonstrate clinical efficacy of a fixed valerian hops extract combination (Ze 91019) in patients suffering from non-organic sleep disorder

https://pubmed.ncbi.nlm.nih.gov/17486686/

• O Kennedy D. et al. (2006) - Anxiolytic effects of a combination of Melissa officinalis and Valeriana officinalis during laboratory-induced stress

https://pubmed.ncbi.nlm.nih.gov/16444660/

• Hieu T. H. et al. ( 2019) - Therapeutic efficacy and safety of chamomile for state anxiety, generalized anxiety disorder, insomnia, and sleep quality: A systematic review and meta-analysis of randomized trials and quasi-randomized trials

https://pubmed.ncbi.nlm.nih.gov/31006899/

• Mao J. J. et al. (2016) - Long-term chamomile (Matricaria chamomilla L.) treatment for generalized anxiety disorder: a randomized clinical trial

https://pmc.ncbi.nlm.nih.gov/articles/PMC5646235/

4) Passionsblume (Passiflora incarnata)

• Harit M. K. et al. (2024) - A Randomized, Double-Blind, Placebo-Controlled, Clinical Study of Passiflora incarnata in Participants With Stress and Sleep Problems

https://pmc.ncbi.nlm.nih.gov/articles/PMC11026993/

• Ngan A. et al. (2011) - A Double-blind, Placebo-controlled Investigation of the Effects of Passiflora incarnata (Passionflower) Herbal Tea on Subjective Sleep Quality

https://pubmed.ncbi.nlm.nih.gov/21294203/

• Dimpfel W. et al. (2008) - Sleep improving effects of a single dose administration of a valerian/hops fluid extract – a double blind, randomized, placebo-controlled sleep-EEG study

https://pubmed.ncbi.nlm.nih.gov/18559301/

• Kyrou I. et al. (2017) -  Effects of a hops (Humulus lupulus L.) dry extract supplement on self-reported depression, anxiety and stress levels in apparently healthy young adults: a randomized, placebo-controlled, double-blind, crossover pilot study

https://pubmed.ncbi.nlm.nih.gov/28742505/

• Chandrasekhar K. et al. (2012) - A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of Ashwagandha Root Extract in Reducing Stress and Anxiety in Adults

https://pmc.ncbi.nlm.nih.gov/articles/PMC3573577/

• Choudhary D. et al. (2017) - Efficacy and Safety of Ashwagandha Root Extract on Cognitive Functions

https://pubmed.ncbi.nlm.nih.gov/28471731/

• Langade D. et al. (2019) - Efficacy and Safety of Ashwagandha Root Extract in Insomnia and Anxiety

https://pmc.ncbi.nlm.nih.gov/articles/PMC6827862/

• Ling Chea K. et al. (2021) - Effect of Ashwagandha on Sleep: A Systematic Review and Meta-Analysis

https://pmc.ncbi.nlm.nih.gov/articles/PMC8462692/

• Panossian A. et al. (2021) - Evolution of the adaptogenic concept from traditional use to medical systems: Pharmacology of stress- and aging-related diseases

https://pubmed.ncbi.nlm.nih.gov/33103257/

• Salve J. et al. (2019) - Adaptogenic and Anxiolytic Effects of Ashwagandha Root Extract in Healthy Adults

https://pmc.ncbi.nlm.nih.gov/articles/PMC6979308/

Vitamin B1 (Thiamin)

• Benton D. et al. (1997) - Thiamine supplementation, mood and cognitive functioning 

https://europepmc.org/article/med/9122365?utm

• Moti M. et al. (2024) - The Effects of Thiamine Supplementation on General Mental Health: triple-blinded randomized placebo-controlled trial

https://www.ijfs.ir/article_706404_d9456a2ce83d04c94d1f2809e23ba70a.pdf

• Tao Y. et al. (2025) - Impact of Vitamin B1 and Vitamin B2 Supplementation on Anxiety, Stress, and Sleep Quality: A Randomized, Double-Blind, Placebo-Controlled Trial

https://pubmed.ncbi.nlm.nih.gov/40507089/ 

• Zandifar A. et al., 2024, Efficacy of vitamins B1 and B6 as an adjunctive therapy to antidepressants in major depressive disorder: randomized, double-blind, placebo-controlled, clinical trial

https://www.sciencedirect.com/science/article/abs/pii/S0165032723013101

Vitamin B3

• Tian S. et al. (2023) - Dietary niacin intake in relation to depression among adults

bmcpsychiatry.biomedcentral.com/articles/10.1186/s12888-023-05188-8

• Wang W. et al. (2012) - Case report of mental disorder induced by niacin deficiency

https://pmc.ncbi.nlm.nih.gov/articles/PMC4198903/

Vitamin B6

• Field D. T. et al. (2022) - High‐dose Vitamin B6 supplementation reduces anxiety and strengthens visual surround suppression

https://pmc.ncbi.nlm.nih.gov/articles/PMC9787829/?utm

• O Kennedy D. (2016) - B Vitamins and the Brain: Mechanisms, Dose and Efficacy — A Review

https://pmc.ncbi.nlm.nih.gov/articles/PMC4772032/?utm

• Schellack N. et al. (2024) - Expert Consensus on Vitamin B6 Therapeutic Use for Patients

https://www.dovepress.com/expert-consensus-on-vitamin-b6-therapeutic-use-for-patients-guidance-o-peer-reviewed-fulltext-article-DHPS?utm

Vitamin B7

• Mahdavifar B., et al. (2021) - Dietary intake of B vitamins and their association with depression, anxiety, and stress symptoms in adults

https://pubmed.ncbi.nlm.nih.gov/33848753/ PubMed

• Reininghaus, E.Z. et al. (2020) – Supplementary Probiotic Treatment and Vitamin B7 in Depression (PROVIT) 

https://www.mdpi.com/2072-6643/12/11/3422

• StatPearls (2025, Übersicht) – Biotin Deficiency 

https://www.ncbi.nlm.nih.gov/books/NBK547751/

• Zielińska M. et al. (2023, Review) – Dietary Nutrient Deficiencies and Risk of Depression. 

https://pmc.ncbi.nlm.nih.gov/articles/PMC10255717/